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Understanding Chronic Inflammatory Response Syndrome (CIRS)

Jacki Meinhardt



In the simplest of terms... 

Chronic Inflammatory Response Syndrome (CIRS) is a progressive, multi-system, multi-symptom illness characterized by exposure to biotoxins. The ongoing inflammation can affect virtually any body organ system and, if left untreated, becomes debilitating.


What is a Water Damaged Building (WDB)?

CIRS WDB is CIRS developed after chronic exposure to the interior of water-damaged buildings typified by resident microbial growth, including bacteria, filamentous fungi (molds), mycobacteria, and actinomycetes, together with resultant biologically produced toxins and inflammagens. Quite often, they aren't obvious.


Diagnosis and Treatment

Patients with CIRS are often misdiagnosed as having depression, anxiety, post-traumatic stress disorder, and somatization, as well as Alzheimer's, Parkinsonism, allergy, fibromyalgia, and chronic fatigue syndrome, among others. Treating patients for these seemingly diverse conditions does not improve their symptoms of CIRS, although effective therapies for CIRS exist. 

CIRS activates the innate immune system, making a proper diagnosis difficult since standard parameters of inflammation are generally negative upon laboratory evaluation.  

CIRS is a brain on fire. A dominant clinical feature of CIRS is the common cognitive complaints of patients, including memory loss, mood disorders, brain fog, loss of executive function, and fatigue. This is unsurprising, considering it is a critical component of the innate immune response. 

Genetic susceptibility is key in CIRS, as not everyone exposed to it will be equally affected by the illness. CIRS can also change gene expression after it occurs, which is entirely different from the genetic susceptibility that occurs from inherited genes. Therefore, genes are essential to understanding how CIRS manifests in a specific person. The role of genetics and gene expression can be tested and are an integral component of diagnosis and personalized treatment planning.

Multiple markers measure the innate response and the presence of inflammation in the brain. Jacki Meinhardt is a world-renowned provider with significant research in this area. 

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Information on this web site is provided for informational purposes only. The information is a result of years of practice experience by the author. This information is not intended as a substitute for the advice provided by your physician or other healthcare professional or any information contained on or in any product label or packaging. Do not use the information on this web site for diagnosing or treating a health problem or disease, or prescribing medication or other treatment. Always speak with your physician or other healthcare professional before taking any medication or nutritional, herbal or homeopathic supplement, or using any treatment for a health problem. If you have or suspect that you have a medical problem, contact your health care provider promptly. Do not disregard professional medical advice or delay in seeking professional advice because of something you have read on this web site. Information provided on this web site and the use of any products or services purchased from our web site by you DOES NOT create a doctor-patient relationship between you and any of the physicians affiliated with our web site. Information and statements regarding dietary supplements have not been evaluated by the Food and Drug Administration and are not intended to diagnose, treat, cure, or prevent any disease.
©2025 by Jacki Meinhardt
www.jackimeinhardt.com

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